Wine is associated with many health benefits, but people who suffer from this medical condition might want to avoid it.

Wine is one of the few alcoholic drinks that, when consumed measuredly, has been associated with positive health benefits. Consuming wine has been linked with lower cholesterol, positive heart health, and more.

But there’s a negative side effect that can appear when people with a certain medical condition consume it.

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According to a study published in the Journal of Allergy and Clinical Immunology, there’s a link between wine consumption and asthma attacks. The study, which looked into the effects of alcoholic beverages and asthma attacks, surveyed over 400 participants and found that 33 percent of them experienced asthma attacks while drinking on at least two separate occasions.

Per the study, wine was the most frequent trigger, with 30% of participants reporting asthma attacks after consuming it. These attacks are usually preceded by symptoms like shortness of breath, wheezing, coughing, facial swelling, sweating, and more. They can occur when taking the first drink or a couple of drinks in. Most medical experts suggest stopping as soon as these symptoms appear since they can quickly grow complicated.

Healthline reports that wine affects people with asthma due to two ingredients that are present in it: histamines and sulfites. Histamines are produced when yeast and bacteria interact, when the alcohol ferments. They’re especially prominent in red wine, which is why this type is riskier for people who suffer from asthma and allergies. Sulfites are also sensitive to people with asthma, with up to 10 percent of people with asthma reacting to it.

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While giving up wine might sound pretty terrible, people who struggle with asthma should be careful when they consume it, especially if their wine of choice is red.

Asthma varies widely from person to person. In some cases, it’s easy to manage, increasing when exposed to certain triggers or when exerting themselves. For others, asthma is a serious condition, having frequent asthma attacks that can even occur while sleeping. It’s up to every person to test and see what works for them and what doesn’t.