Saturday, June 15, 2024

Why Eating Marijuana Edibles On An Empty Stomach Is Not A Good Idea

Much like alcohol, cannabis edibles are best taken with food. Not doing this can result in anxiety and a paranoia freakout. But why?

Some believe the Rate of Absorption Hypothesis that states edibles cause increased anxiety when taken on an empty stomach because THC is absorbed at a quicker rate.

But according to the Prof of Pot, who broke down some recent studies on the issue:

I call bullshit because compared to either fasted or fed, the absorption is 100 times faster when cannabis is smoked. Furthermore, plasma concentrations of THC after a meal don’t lag the fasted state by that much – the time to peak plasma concentrations is only much later after a meal because so much more is absorbed.

Others think that formation of the 11-OH-THC metabolite is responsible. Prof of Pot says though 11-OH-THC is probably more potent than THC:

It is true that 10 times more 11-OH-THC can be formed after taking cannabis edibles than any other route such as smoking. However, the peak concentration of 11-OH-THC in the fasted state is only 25% higher than in the fed state. That is not a big enough difference to convince me that 11-OH-THC is the culprit.

Prof thinks the extra anxiety is due to the ratio of THC to CBD under fasted conditions:

Because the activity of 11-OH-THC is at least as strong as THC, I summed the levels of THC and 11-OH-THC for a measure of ‘total THC’. I then examined the ratio with CBD and the results were surprising.

After a meal, the ‘total THC’ to CBD ratio was about 3 at the time of peak blood concentrations. This is already on the high side (no pun intended). However, this ratio after fasting was almost 9 –  nearly 3 times higher than after a meal.

So eating a cannabis edible on an empty stomach, even if it contains a 1:1 ratio, is the equivalent of smoking a cannabis strain with a 9:1 THC to CBD ratio!

Prof surmises that anxiety is “due to the relatively low absorption of CBD compared to THC when you haven’t eaten” and suggests taking edibles after a solid meal (preferably one with some fat to stimulate bile acid release), especially if you are taking edibles with CBD.


Can Cannabis Pair Well With A Wine Dinner

They have each become popular, especially with the under 40s...but can cannabis pair well with a wine dinner?


Marijuana Might Help The Liver After Bing Drinking

Over one-quarter of people aged 30 to 50 do it, research shows marijuana might help the liver after bing drinking.

Don't Miss Your Weekly Dose of The Fresh Toast.

Stay informed with exclusive news briefs delivered directly to your inbox every Friday.

We respect your privacy. Unsubscribe anytime.