Saturday, June 15, 2024

CBD Amplifies The Adverse Effects Of THC, New Study Finds

Contrary to what we’ve been told in the past, researchers have now found that CBD inhibits the breakdown (metabolism) of THC, thus increasing its adverse effects.

A new study has unearthed a controversy on the interaction between the psychoactive cannabinoid THC and its mellow counterpart CBD. For the longest time, it’s been believed that combining CBD with THC enhances the therapeutic benefits of both while limiting some of the adverse effects attached to THC. What if CBD amplifies the adverse effects of THC?

The exact mechanisms have been hypothesized with the message being loud and clear: CBD is THC’s perfect complement and antidote. But results from this new study found that this is not entirely the case.

medical cannabis
Photo by mikroman6/Getty Images

Details of the study

A group of researchers from the Behavioral Pharmacology Research Unit at Johns Hopkins University conducted a randomized clinical trial to investigate the effects and side effects of cannabis edibles containing both THC and CBD in equal amounts.

The study model was a double blind crossover that included 18 healthy adults. This involved three randomized outpatient test sessions; each session one week apart. The participants were divided into three groups and offered brownies containing either of the three:

  • No cannabis extract (placebo)
  • 20 mg Δ9-THC with no CBD
  • 20 mg Δ9-THC + 640 mg CBD

The group that received CBD in addition to THC experienced more severe adverse effects compared to the THC only group. Researchers found that CBD inhibits the breakdown (metabolism) of THC, thus increasing its adverse effects by increasing circulating levels and active metabolite.

Contradictory Evidence: Is There an Ideal Way to Mix CBD With THC?

There are a number of studies that contradict the major claim in this article, that CBD worsens the adverse effects of THC. Let’s look at a few:

A 2019 study was conducted by the Western University to investigate how CBD affects the psychiatric side effects of THC. The rats offered THC were more anxious and fearful while the rats that were offered both CBD and THC were less anxious and fearful.

RELATED: Does CBD Minimize The Harmful Effects Of THC? New Study Has Answer

The researchers found that CBD attenuates some of the psychotropic side effects caused by THC by inhibiting THC’s ability “to overstimulate the ERK pathway.” The results of the study were published in the Journal of Neuroscience.

A different systematic review investigated the influence of CBD on the acute effects of THC. The researchers found that in most studies CBD reduced the adverse effects of THC. However,  these studies have used different ratios of THC to CBD.

RELATED: If THC Percentage Doesn’t Matter, Why Not Just Smoke CBD?

With the medical cannabis industry taking shape, it’s imperative to speed up research so as to find the best ways to offer cannabinoids to patients.

This article originally appeared on and has been reposted with permission.


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