Cannabis In Cancer Treatment: Feds To Fund New Research

Benzinga Staff Writer

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May 10, 2022

Cannabis In Cancer Treatment: Feds To Fund New Research

National Institutes of Health said that research about the health effects of cannabis use remains limited, even though one in four cancer patients have reported using cannabis products to manage their symptoms.

In cancer patients, cannabinoids have primarily been used as a part of palliative care to help alleviate pain, reduce inflammation, relieve nausea and stimulate appetite.

However, with the field evolving rapidly over the past years, thanks to both legislative efforts and push from marijuana advocates, some early clinical trials and studies of cannabinoids in treating cancer in humans have been in motion lately.

marijuana research — Photo by Aleksandr_Kravtsov/Getty Images

Last week, the federal government took a step forward in promoting financing opportunities for researchers to study the benefits and risks of marijuana for patients who have cancer.

National Institutes of Health (NIH) said on Thursday in a notice of special interest that research about the health effects of cannabis use, including both potential harms and benefits, remains limited, even though one in four cancer patients have reported using cannabis products to manage their symptoms.

NIH’s National Cancer Institute said that the request seeks to “promote research in understanding the mechanisms by which cannabis and cannabinoids affect cancer biology, cancer interception, cancer treatment and resistance, and management of cancer symptoms.”

The agency provided an overview of the existing research into the connection between cannabis and cancer, as well as a list of the following areas of interest that researchers should investigate:

Understanding how exogenous cannabis and cannabinoids affect cancer development (preneoplasia through malignancy) and biology, including the tumor microenvironment;
Understanding how endogenous cannabinoid pathways influence cancer development and biology;
Defining the effects of cannabis and cannabinoids on cancer treatment (particularly targeted treatments and immunotherapy) and the development of treatment resistance;
Understanding the use of cannabis and cannabinoids in cancer interception and delineating how endocannabinoid signaling pathways may inhibit early cancers;
Defining the mechanisms of cannabis and cannabinoid action in alleviating symptoms of cancer and cancer treatment (such as pain, nausea, and neuropathy);
Understanding the combinatorial effects of cannabis and cannabinoids in conjunction with other factors (such as tobacco constituents, alcohol, microbiome or diet) on cancer biology, treatment and symptom management;
Identifying biological mechanisms underlying disparities in sex or ethnicity in cannabis and cannabinoid action in cancer biology, treatment or symptom management; and
Developing or validating new and human-relevant model systems to understand cannabis and cannabinoid action in cancer biology, treatment or symptom management.

cancer chemotherapy — Photo by FatCamera/Getty Images

The agency also said that epidemiological studies of cannabis use and cancer risk “have yielded limited and inconsistent results,” adding that “studies that integrate expertise from multiple disciplines, incorporate state-of-the-art, human-relevant models (e.g., organoid or patient-derived xenograft models) and utilize advanced technologies and methods are strongly encouraged.”

Cannabinoids In Cancer Treatment

So far, several studies have yielded encouraging results.

Researchers at the Medical College of Georgia at Augusta University provided some hope to those suffering from brain tumors through a new study that revealed that inhaled CBD shrinks the size of glioblastoma tumors in an animal model.

Last year, Cancer charities and the U.K.’s National Health Services (NHS) launched a study to determine whether Sativex, a cannabis-based mouth spray, combined with chemotherapy medication -temozolomide – can help kill glioblastoma tumor cells and extend the overall length of patients’ lives.

Another study, conducted by Hadassah Medical Center physicians, revealed a sixfold improvement in killing breast cancer cells when using specific Cannabotech’s (CNTC.TA) medical cannabis products in combination with standard oncology treatments and drug protocols – chemotherapy, biological and hormonal, over the existing treatment.

Moreover, Cannabotech, which is also involved in the development of a botanical drug based on an extract of the Cyathus striatus fungus and a cannabinoid extract from the cannabis plant, reported last month that in experiments conducted on a cell model, the fungus extract eliminated 100% of pancreatic cancer cells relatively selectively and without damaging normal cells.

Marijuana & Research

In the meantime, the York County, PA-based Groff North America recently claimed to be the first company in the U.S. to introduce its cannabis crop for legal medical research. The news came some ten months after the DEA announced it would begin approving applications allowing some marijuana growers to become federally authorized to cultivate the plant for research purposes.

White House press secretary Jen Psaki recently said that approving additional cannabis manufacturers for scientists is “a key step in promoting research because it broadens the amount and quality of cannabis available for research purposes.”

This article originally appeared on Benzinga and has been reposted with permission.

The Latest On Medical Cannabis For Autism

Terry Hacienda

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May 10, 2022

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The Latest On Medical Cannabis For Autism

There are more studies ongoing to help shed light on how the body and endocannabinoid system in autistic people respond to cannabinoids.

Around 1% of the global population has autism spectrum disorder (ASD), and this number is gradually increasing since doctors are becoming more adept at diagnosing it. Science has been working hard to figure out ways to combat it, but it slow going. Here is the latest on medical cannabis and autism.

It can be painful and challenging to have a loved one struggling with symptoms of autism. In extreme cases, this can include self-harming, aggression, and severe anxiety. Despite all the advances in medicine, we still don’t have a cure for autism spectrum disorders, though the treatments available are mostly focused on symptom management so that these don’t disrupt the daily lives of those with this condition. Since it affects everyone differently, the symptoms vary greatly as well, which is why tailored treatment plans are necessary.

Could Cannabis Be Better At Treating Autism In Kids Than Traditional Meds? — Photo by Anthony Fomin via Unsplash

Currently, psychotherapy and prescription medication are the two main types of treatments being used for individuals with autism. Many types of psychotherapy are used depending on the symptoms; these may include one or some: physical therapy, occupational therapy, assistive technology, speech therapy, or applied behavioral analysis. For medication, the FDA has only approved two: Risperdal, and Abilify, which are antipsychotic medications designed to reduce aggression and irritability.

Treating and managing autism can be extremely difficult, but thankfully, cannabis has been shown to be beneficial in children as well as adults with this condition.

What The Studies Say

A recent review led by Mariana Babayeva, a Touro College of Pharmacy in New York professor, revealed that there is a growing body of clinical studies that have shown promising results using cannabis to treat autism spectrum disorder.

“Due to its vital role in regulating emotion and social behaviors, the endocannabinoid system represents a potential target for the development of a novel autism therapy,” reads the study. The authors also added “several studies have suggested that dysfunctions in the components of the endocannabinoid system may contribute to the behavioral deficits and neuroinflammation observed in autism.”

Within the medical community, it’s also a widely accepted hypothesis that since the receptors of the endocannabinoid system can be found in the central nervous system, this explains the link between cannabinoids and improvements in autism symptoms.

In 2020, researchers from Boston’s Tufts University revealed that when they worked with kids as well as young adults who had ASD but medicated with hemp-based or cannabis products, 60% among those with aggression caused by ASD reported that they noticed improvements after treatment. Meanwhile, 91% of those who had both ASD and epilepsy saw improvements in seizures.

Then in 2021, a clinical review of existing literature on cannabis for autism concluded that, “Cannabis products have been demonstrated to reduce the number and/or intensity of different symptoms, including hyperacidity, attacks of self-mutilation and anger, sleep problems, anxiety, restlessness, psychomotor agitation, irritability, aggressiveness perseverance, and depression. Moreover, they are associated with an improvement in cognition, sensory sensitivity, attention, social interaction, and language.”

the potential of cbd and cannabis within the anxiety and autism community — Photo by Fernando @dearferdo via Unsplash

The study’s authors then concluded that, “Cannabis and cannabinoids may have promising effects in the treatment of symptoms related to ASD, and can be used as a therapeutic alternative in the relief of those symptoms.”

In the medical community, it has become clear that while the research on cannabis for autism is still in its early stages, it has been nonetheless controversial. That hasn’t stopped families from asking doctors and seeking professional medical advice on the use of cannabis for autism symptoms because there are significant cases of anecdotal evidence that it can be helpful for many of its symptoms especially when it comes to calming down aggression and reducing seizures. Cannabidiol (CBD) has especially been noted as helpful because it’s non psychoactive, and has a long track record in treating seizures safely, even for children.

In fact, many parents feel so strongly about the use of medical marijuana for treating autism symptoms. A parent advocacy organization called the Mothers Advocating Medical Marijuana for Autism (MAMMA) has chapters in several states; in their website, one can find numerous testimonials from families who say that cannabis has helped their children. What is sad is that many of these families are medical refugees who had to relocate states just so that their kids could benefit from states with medical marijuana laws where it can be used for seizures and other symptoms. There have been families that have also sent in their testimonials anonymously, saying that they have used cannabis illegally because we still don’t have the legislations in place enabling autistic people to use cannabis.

There are currently 14 states that list autism as either a qualifying condition or a debilitating condition, but that isn’t enough. No matter where you live, you must be able to have access the medicine that can help make a difference in your life, even if you choose to medicate your child with cannabis.

Conclusion

There are more studies ongoing to help shed light on how the body and endocannabinoid system in autistic people respond to cannabinoids. While the exact mechanisms are still much of a mystery, we can at least say that cannabinoid compounds work for autism. However, the efficacy, type of cannabis product, and dosage taken all play a role too. There is some research that says THC taken with CBD is best while others say CBD alone is best.

While cannabis can help, parents who want to give their children cannabis for medicine should keep in mind that it should not be seen as a cure-all. At best, cannabis probably works more effectively with other autism therapies. Speak to your doctor or one in a state that has legalized the use of cannabis for autism to find the best route for you or your loved one.

This article originally appeared on Cannabis.net and has been reposted with permission.

It’s Possible To ‘Factory Reset’ Your Brain To Get Rid Of Different Disorders, According To Study

News

Maria Loreto

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May 9, 2022

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It’s Possible To ‘Factory Reset’ Your Brain To Get Rid Of Different Disorders, According To Study

A new study claims to erase and manage conditions like anxiety and alcohol abuse via gene editing.

The brain has control over most things in our body. This pivotal organ is responsible for our moods, memories, thoughts, and so much more. Now, a new study suggests that it could be possible to give your brain a “factory reset,” as if it were an iPhone, and that this could help get rid of conditions like alcohol abuse and anxiety.

The study, published in the journal Science, focused on localizing the region of the brain responsible for the development of alcohol abuse and anxiety, showing how gene editing can erase or control people’s predisposition to these diseases.

Researchers from the University of Illinois based this study on previous findings that linked binge drinking in adolescence to altered brain chemistry, which could impact the way these people regulate their emotions, resulting in higher odds of having anxiety or alcohol abuse. The goal of their study was to use modern gene editing and figure out if these effects could be reversed.

Can CBD, Psilocybin Help Fight Alcohol Abuse? — Photo by crotography/Getty Images

The study was conducted on rats that were exposed to alcohol in their adolescence. Once the rats reached adulthood, researchers measured their levels of anxiety and their desire for alcohol by conducting different tests, including maze experiments and having them choose between different liquids.

Researchers highlighted the importance of adolescent drinking, which can lead to alcohol abuse later on and, more concerning, psychiatric disorders. They found that those who drink during their adolescence have less of a protein known as Arc. The gene-editing process is called CRISPR-d Cas9, and consists of cutting out DNA and allowing it to naturally replenish itself.

“Adolescent binge drinking is a serious public health issue, and this study not only helps us better understand what happens in developing brains when they are exposed to high concentrations of alcohol but more importantly gives us hope that one day we will have effective treatments for the complex and multifaceted diseases of anxiety and alcohol use disorder,” said the study’s lead author, Subhash Pandey. “That this effect was seen bidirectionally validates the significance of the Arc enhancer gene in the amygdala in epigenetic reprogramming from adolescent binge drinking.”

The brain goes through significant changes when people are going through their adolescence. It goes through complex rewiring and pruning of neurons, making it sensitive to outside substances, like alcohol and even cannabis.

Thailand Is Giving Away A Million Cannabis Plants

Benzinga Staff Writer

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May 9, 2022

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Thailand Is Giving Away A Million Cannabis Plants

Thailand residents will be permitted to legally cultivate “as many cannabis plants” as they wish in their own homes as of June 9.

By Nina Zdinjak

After Thailand became the first Southeast Asian country to legalize medical cannabis in 2018, this January it became the first in Asia to legally allow marijuana. Under the new regulation, which officially takes action on June 9, its residents are allowed to cultivate cannabis for personal use.

The country’s Public Health Minister Anutin Charnvirakul announced on Sunday that he plans to give away a million marijuana plants, reported Nation Thailand.

Anutin said that Thailand residents will be permitted to legally cultivate “as many cannabis plants” as they wish in their own homes as of June 9. While official registration is not required for home cultivation, all plants must be medical grade for medicinal purposes.

The Minister highlighted the advantages of commercial cannabis cultivation.

Under the law in Thailand, registered businesses are allowed to sell marijuana products with less than 0.2% THC. Anutin added that under the new law, individuals can operate marijuana-related companies.

“This will enable people and the government to generate more than 10 billion baht ($289.46 million) [per year] in revenue from marijuana and hemp,” he said. “Meanwhile, people can showcase their cannabis and hemp-related products and wisdom and sell their products nationwide.”

Marijuana entrepreneurs and businesses would be allowed to compete freely, as there would be no concessions, Anutin added.

While small businesses selling marijuana-related products are not required to register with the FDA, bigger operators must obtain permission from the agency.

Cannabis advocates in the country believe that looser cannabis laws could help speed up economic recovery after the pandemic. It is expected that the new marijuana laws could help push for the boom in the country’s tourism industry. Experts from the travel industry have said they believe the market will blossom like the marijuana plant itself.

“Thailand is well known as a destination for medical tourism and wellness travel. So, these sectors will surely benefit from the latest developments,” commented Dirk De Cuyper, CEO of S Hotels and Resorts.

This article originally appeared on Benzinga and has been reposted with permission.

State-By-State Guide To Cannabis Age Requirements

Terry Hacienda

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May 9, 2022

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State-By-State Guide To Cannabis Age Requirements

While you may want to buy legal cannabis at the age of 18, that will be quite impossible since provisions and policies put in place by weed legalized states do not permit it.

This article originally appeared on Cannabis.net and has been reposted with permission.

Election Day 2012 saw voters in Colorado approve a ballot initiative to legalize the recreational sale and use of cannabis. This bold step by the citizens of Colorado saw the state become the first to do so in all of the United States.

Since then, 17 other states, Guam, and Washington, D.C., have followed suit, and public support for cannabis legalization has significantly grown. However, the recreational use of cannabis is still very much illegal at the federal level.

marijuana saless — Photo by Ivan-balvan/Getty Images

While many states have legalized the recreational and medical use of cannabis, the approach and policies of each state differ. To this end, a young person needs to know what applies in each state to avoid the wrath of the law.

Here are the states where the recreational sale and use of cannabis is legal:

Colorado
Alaska
Washington
Oregon
California
Washington, D.C.
Maine
Nevada
Massachusetts
Michigan
Connecticut
Guam
Vermont
Illinois
Montana
Arizona
New Jersey
Virginia
New York
New Mexico

As mentioned earlier, each of these states has specific provisions for the buying, sale, and amount of cannabis an adult can legally possess. These states also have different rules as regards adult growing cannabis plants for personal recreational use. However, one similarity these states share is that individuals above the age of 21 years can legally buy and use cannabis for recreational purposes. Here are the provisions and legalization measures in each state.

Colorado

In Colorado, adults above the age of 21 years can give away and also possess a maximum of one ounce of cannabis. Adults are also allowed to cultivate six cannabis plants each. Although, residences are restricted to a maximum of 12 plants regardless of the number of people residing there. Public consumption of cannabis is also illegal in Colorado.

Washington

In Washington, adults above the age of 21 years can possess and buy a maximum of 16 ounces of solid cannabis-infused edibles, an ounce of cannabis, 7 grams of cannabis concentrated, and 72 ounces of liquid cannabis-infused products. However, public consumption of cannabis is also illegal in Washington, and adults are banned from growing cannabis plants for personal recreational use.

Alaska

In Alaska, adults above the age of 21 years can possess and buy a maximum of one ounce of cannabis and can cultivate a maximum of six cannabis plants. Public consumption of cannabis is also illegal in Alaska. You can visit any of the licensed dispensaries to buy cannabis legally within the state.

Oregon

The state of Oregon allows adults above the age of 21 years to buy or possess a maximum of one ounce of cannabis in public and a maximum of 8 ounces on private property. Adults are also allowed to possess a max of 16 ounces of solid cannabis-infused edibles or 72 ounces of liquid cannabis-infused products. Adults can also grow a max of four marijuana plants while public use of cannabis is illegal across the state.

Washington, D.C.

Adults in Washington D.C., can buy or possess a max of 2 ounces of cannabis and can gift a max of an ounce to another person. It is also legal for adults to grow a max of six cannabis plants in their homes. However, as of now recreational sale of cannabis is illegal in D.C.

California

Adults above the age of 21 years can buy, possess, or gift a max of one ounce of marijuana and a max of 8 ounces of concentrated marijuana. Public consumption of marijuana is prohibited and illegal.

Photo by Ethan Miller/Staff/Getty Images

Maine

Adults above the age of 21 years can buy, possess, or gift a max of one-ounce cannabis and grow a max of 12 young cannabis plants and 6 flowering plants.

Massachusetts

Adults above the age of 21 years can possess a max of one ounce of cannabis in public space and a max of 10 ounces on private property. Adults are also allowed to cultivate six cannabis plants each. Although, residences are restricted to a maximum of 12 plants regardless of the number of people residing there.

Nevada

Adults above the age of 21 years can buy or possess, a max of one ounce of marijuana and a max of ⅛ of an ounce of concentrated cannabis. Adults are also allowed to cultivate six cannabis plants each or 12 cannabis plants for every household.

Michigan

Adults above the age of 21 years can buy or possess, max of 2.5 ounces of marijuana and a max of 15 grams of concentrated cannabis. Adults are also allowed to cultivate 12 cannabis plants for every household.

Vermont

The state of Vermont makes legal, only the possession and cultivation of cannabis plants. Both the sale and purchase of cannabis are illegal in the state. However, that will change come October 2022 once the state starts giving out licenses.

Presently, adults above the age of 21 years in Vermont can possess a max of an ounce of marijuana. Adults can also cultivate four immature and two mature cannabis plants for every household.

Guam

Adults above the age of 21 years in Guam can possess a max of an ounce of marijuana. Adults can also cultivate a max of six cannabis plants (max of three mature plants)

Illinois

The state of Illinois makes it legal for adults above the age of 21 years to possess 5 grams of concentrated marijuana, 30 grams of marijuana, and cannabis products with a maximum of 500mg of THC. While it’s legal to purchase these at the local dispensaries, public consumption is prohibited.

New Jersey

The state of New Jersey makes it legal for adults about the age of 21 years to use cannabis both for medical and recreational use. Specific provisions are still under review.

Montana

The state of Montana makes it legal for adults about the age of 21 years to use cannabis both for medical and recreational use

South Dakota

Adults in South Dakota above the age of 21 years can distribute and possess a max of one ounce of cannabis.

Arizona

Adults in Arizona above the age of 21 years can distribute and possess a limited amount of cannabis. While the provisions are still in the works, it has been speculated that public consumption will be banned and cannabis offenses will be cleared.

New York

The state of New York makes it legal for adults above the age of 21 years to possess a max of 3 ounces of marijuana for recreational use. Individuals previously convicted of marijuana will have their offense records cleared.

Virginia

In Colorado, adults above the age of 21 years can give away and also possess a maximum of one ounce of cannabis for recreational use. Adults are also allowed to cultivate a max of four marijuana plants.

New Mexico

The state of New Mexico makes it legal for adults above the age of 21 years to possess a max of 2 ounces of marijuana. Adults are also allowed to cultivate six cannabis plants each or 12 cannabis plants for every household.

Connecticut

The state of Connecticut makes it legal for adults above the age of 21 years to possess a max of 1.5 ounces of marijuana for recreational use. It is also legal for adults to possess a max of 5 ounces of weed in their homes or vehicles. The sale of legal cannabis is expected to kick off in the summer of 2022.

Conclusion

While you may want to buy legal cannabis at the age of 18, that will be quite impossible since provisions and policies put in place by weed legalized states do not permit it. You will need to wait a few extra years to buy your first legal cannabis, however, it’s best you still note the provisions peculiar to your state so you don’t fall ignorant of the law.

This article originally appeared on Cannabis.net and has been reposted with permission.

Why Is The World’s Largest Cannabis Market Shooting Itself In The Foot?

Cannabusiness

Benzinga Staff Writer

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May 9, 2022

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Why Is The World’s Largest Cannabis Market Shooting Itself In The Foot?

Due to exorbitant taxes, California’s legal cannabis market has not come anywhere near to meeting its expectations in terms of size.

By Maureen Meehan

Taxes in California are among the highest in the United States and that of course includes cannabis-related taxes, which are so exorbitant that they are hobbling what should rightly be the country’s — make that the world’s largest and potentially successful cannabis market.

High taxes and onerous regulations are keeping unlicensed cultivators out of the legal market and contributing to illicit sales, which make up whopping three-quarters of all weed sales in California today, according to a new study done by Reason Foundation, Good Farmers Great Neighbors and Precision Advocacy.

california cannabis — Photo by Rex_Wholster/Getty Images

Taxed at a flat rate of about $161 a pound, on top of which there is a 15% excise tax, as well as local cultivation, manufacturing, processing, distribution and retail taxes. As a result, California raked in nearly $1 billion in cannabis tax revenue during the first three quarters of 2021, yet the cannabis industry is drowning.

Cultivation Tax Has To Go

“High taxes are undermining California’s legal cannabis market,” says Geoffrey Lawrence, director of drug policy at Reason Foundation. “California could double monthly cannabis tax revenues by 2024 by eliminating the cultivation tax. Without the cultivation tax, our data show lower cannabis prices would increase sales of legal products, increasing the state government’s general sales tax revenue and more than replacing losses from the eliminated cultivation tax.”

The Market Is Stunted

Due to exorbitant taxes, California’s legal cannabis market has not come anywhere near to meeting its expectations in terms of size. Indeed, the market is just one-third the size of that which was expected, based on its population of around 40 million and high adult weed consumption rates.

That is to say, nearly two-thirds of cannabis sales in California are still taking place on the illicit market, the study estimates.

Weed Taxes Compared To Neighboring States

California’s state and local taxes on legal cannabis are as high as $90 per ounce, or $1,441 per pound. By comparison, cannabis taxes average $340 per pound in Oregon and $526 a pound in Colorado.

Due to these lower taxes and greater access to legal products, residents in Oregon spend 378% more per capita on legal cannabis. Colorado residents spend 335% more per capita on legal cannabis than Californians spend, the report showed.

“We are experiencing first-hand a serious price compression in the California supply-chain in part as a result of the illegal market, high taxes and fees and a patchwork of inconsistent local taxes driving legal operators to the brink of a financial cliff,” said Amy O’Gorman Jenkins, president of Precision Advocacy and legislative advocate of the California Cannabis Industry Association. “We cannot allow the largest cannabis market in the world to fail.”

Farmers face the biggest challenge, and some are giving up.

“Many farmers are considering going fallow this year. Busy Bee Organics, one of the first woman-owned, sun-grown farmers in Santa Barbara, has already declared she’s not planting this year,” said Sam Rodriguez, policy director of Good Farmers Great Neighbors.

marijuana crop — Photo by Lealnard Riengkaew / EyeEm/Getty Images

No Farmers, No Weed: What’s To Be Done?

“The immediate elimination of the cultivation tax would be a first step in addressing critical issues impacting the state’s legal cannabis market from seed to sale,” Rodriguez said.

Another shocking statistic: Oregon (pop. 4.2 million) has one legal cannabis retailer for every 6,145 residents (some say the highest per capita in the world!). Colorado (pop. 5.8 million) has one legal retailer for every 13,838 residents while California has just one legal cannabis retailer for every 29,292 residents, the study found.

This article originally appeared on Benzinga and has been reposted with permission.

An Essential Guide For Returning Cannabis Users

Maria Loreto

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May 8, 2022

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An Essential Guide For Returning Cannabis Users

Cannabis has never been easier to access. Here’s a quick guide for returning users.

As cannabis becomes legal in a growing number of states, its use is becoming increasingly popular. And while many newbies are giving it a shot, there are a lot of people who are finding themselves returning to cannabis as they enter a new stage in their lives, using it for medicinal or recreational purposes.

While more plentiful than ever, the new cannabis world can be overwhelming to navigate. With federal laws and states having different rulings on the drug and how it operates, it’s difficult to jump back in without some guidance. Fear not ⁠— here’s a basic guide for returning weed users.

Is weed stronger now?

seniors and cannabis — Photo by Westend61/Getty Images

One of the most common things you’ll read now when looking into cannabis is how much stronger it is when compared to years past. And while weed is stronger than it was before, it still shouldn’t be a determining factor on whether or not you’ll be consuming it or not. According to the National Institute on Drug Abuse, THC potency averaged out at 15% in 2018. 30 years ago, it averaged out at 4%.

What is CBD?

children and CBD — Photo by CasarsaGuru/Getty Images

The CBD trend entered full force only a couple of years ago. It’s understandably puzzling for people, some of whom don’t even know that the compound is a part of the cannabis plant, and other who don’t understand the differences between it and THC, its more psychoactive complement.

CBD and THC are just two of cannabis hundreds of cannabinoids. The main difference between the two is that THC will get you high, while CBD will most likely not. Research on CBD is new, but some believe it can be used to treat forms of anxiety, depression and promote relaxation.

What method is best?

Are Stoners Ditching Joints For Dabs And Vapes? — Photo by OlegMalyshev/Getty Images

Choosing whether to eat an edible or to smoke, vape, dab, etc. is confusing. There’s too many options. The best way to choose a method is to keep an open mind and experiment what results you like best, starting off slow.

Edibles tend to produce stronger highs, making them great for recreational and medicinal use alike. The caveat is that they take a long time to affect people, something that makes it easier for them to overdose. When purchasing these products, it helps to ask your budtender and explain your current situation. They may suggest a dosage for you, something that can help you once you purchase your product and read the amount of THC per serving.

On the other hand, smoking and vaping produces quick results usually, within 30 minutes of consuming. This makes for more accessible highs, especially for beginners.

What about bad highs?

People With Anxiety Or Depression May Be More Likely To Overuse Cannabis, Says Study — Photo by Fernando @cferdophotography via Unsplash

Bad highs can happen, especially with edibles. While cannabis remains a pretty safe activity, a bad high can be scary, especially if you’ve had no experience with them. These moments usually involve a lot of anxiety and stress, with symptoms like paranoia, nausea and drowsiness affecting people. The key is to stay calm and wait the high out. There are no clinical consequences to bad marijuana highs, just a bit of a stressful time.

How do I navigate a dispensary?

This Iconic Chain Restaurant Could Be Your New Dispensary — Photo by Health Korvola via Getty

Dispensaries are great, having experts on staff and making people feel like they’re buying a bottle of wine and not like they’re buying something illegal from their dealer. Still, each state has different rulings, meaning that dispensaries can be very different from each other. Be sure to call ahead of time or browse their website in order to get an understanding of what they have and don’t be afraid to ask questions. Times are changing and we’re living in the midst of an adjustment period; take advantage of it and use it all to learn.

Argentina Legalizes Medical Cannabis And Industrial Hemp

Benzinga Staff Writer

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May 8, 2022

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Argentina Legalizes Medical Cannabis And Industrial Hemp

South America’s cannabis marketplace shows signs of promise as incremental progress has been underway for several years. Recently Argentina Legalizes Medical Cannabis

By Nicolás Jose Rodriguez

Argentina legalizes medical cannabis. Congress approved a law that will create a regulatory framework for public and private investments in the production of pharma-grade cannabis products.

The law still needs to be signed by President Alberto Fernandez. Lance Lambert, VP of marketing and business development for Nevada-based brand GreenBroz Inc., said the country’s population of over 45 million is “one to watch and be ready to take advantage of when the time is right.”

The law passed the Senate last year, with ample support from state governors who are betting on cannabis to promote economic growth and sustainable development.

The legislation does not legalize recreational cannabis, rather, creates the ARICCAME (Regulatory Agency for Hemp and Medicinal Cannabis), the agency that will regulate the production of cannabis for medicinal and industrial purposes.

The agency will coordinate with state governments when and if cannabis and hemp licenses are approved, gaining a prominent role in the regulatory process.

The law also provides cannabis businesses with access to traditional banking and establishes a streamlined regulatory process for hemp producers.

Thursday’s decision in the Chamber of Deputies has been pending since July of last year when, after being proposed by the national government, it was later blocked by the opposition over disagreement on the details.

Divided Opinions

Representatives in favor of the bill emphasized the importance of legislation to guarantee safe access to healthcare, boost economic benefits and exports, and diversify economies beyond the central “Pampa” region.

Meanwhile, opponents of the bill said the legislation enlarges the government and challenges the imposition of a national tax on cannabis. There were also cultural arguments against cannabis. Conservative members of the lower chamber referred to the cannabis industry as “the advance of drug trafficking” and legitimization of the consumption of illegal substances.

“This law provides for different types of authorizations and licenses. Priority will be given to projects that promote regional development and that incorporate SMEs“, said Rep. Mara Brawer, co-sponsor of the bill.

There were a few surprises as the debate played out.

Rep. Martin Tetaz, a supporter of market deregulation and fiscal austerity, often criticized by the left, said he was in favor of the law and called for the legalization of recreational cannabis.

“I am in favor of complete legalization, and against a ‘paternalistic state’. Society does not tolerate more bureaucracy,” Tetaz said in reference to the regulatory agency that will serve as the supervising body of the cannabis production chain.

Argentina’s cannabis marketplace shows signs of promise as incremental progress has been underway for several years. The Supreme Court decriminalized the use of small amounts of cannabis in 2009. In 2017, the country approved the import of cannabis products with a doctor’s prescription, and in 2020, a bill authorized home cultivation for medical patients.

This article originally appeared on Benzinga and has been reposted with permission.

The Most Expensive Cannabis Strains On The Market

Cannabis

Terry Hacienda

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May 8, 2022

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The Most Expensive Cannabis Strains On The Market

Not everyone can afford the most expensive strains on the market. These affordable alternatives with great cannabinoid profiles are a solid option.

You may be shocked to know that many of the expensive, premium cannabis strains on the market—past and present—have affordable alternatives. There’s no need for spending hundreds of dollars on growing or purchasing a cannabis strain with high-quality genetics when you can settle for its cheap counterparts.

Dispensaries in most parts of the world group strains by price. Some of these products are priced on the high side, based on their fanciful names and the expensive cultivation techniques used to produce them. Yes, all cannabis strains do not have a standard breeding process. Some strains are produced by the citizen science approach—a system where growers irregularly play around with cannabis genetics to put out something unique. This approach produces nothing laudable, but a few times, it results in cannabis strains with the best of the best genes.

What Are Skunk, Haze, And Kush? The Foundation Of Today's Cannabis Strains — Photo by msk.nina/Getty Images

Multiple strains were produced from extensive cannabis breeding practices. Here, high-tech-grade equipment and world-class genetic materials are handled by highly-skilled, experienced breeders. The products created here are often priced based on the input into the program, irrespective of the origin of the plant. Most of these strains emerge at far higher prices than regular strains.

The point is that some of these premium seeds are not worth the price tags they come with. Only a few are. While I won’t excuse the fact that these premium strains offer unique impacts, I’d like to point out that some are actually over-hyped for easy marketing and quick sales. There are far better strains with better generic qualities and “psychoactive” highs than these premium, high-priced strains.

To further drive my point home, I’ve highlighted some of the most expensive cannabis strains across the globe and relatively cheaper alternatives that you can grow or use instead. That is, at a fraction of the intended price, you get to experience a similar experience.

Fruity Pebbles

Fruity pebbles have been out of style for a while now. Most growers, breeders, and consumers can testify to how this strain came and went like it was nothing.

Fruity pebbles emerged as a limited-time offer from Alien Genetics. The seed bank geneticists created this hybrid by mixing the Granddaddy Purple, Tahoe Alien, and Green Ribbon strains. With such powerful parent strains, fruity pebbles had no choice but to live up to their tantalizingly sweet reputation.

The strain exhibited some uniquely tempting effects that leaned more towards the indica morphology. The plant grew in a dense canopy fashion and was characterized by large, broad leaves with lateral growth. The buds were laden with very high levels of THC, making the product capable of a stoning body high. Even experienced veteran cannabis users could not escape the couch-lock effect of using fruity pebbles.

During the limited period fruity pebbles were sold, the scientists at Alien Genetics did not feminize them. Even if they did, the feminized strain never hit the market. Enthusiastic growers had to buy the seeds and hope for the universe to present them with a feminized plant. This would have been acceptable if each seed wasn’t priced at $1,500. In the long run, the unreal terpene and cannabinoid profile weren’t worth the exorbitant rate.

Cheap Alternative: Runtz

Developed by Zamnesia’s genetics team, the Runtz strain is a better-tasting and more potent strain with similar effects to fruity pebbles. The breeding team discovered that Runtz was produced by crossing Zkittlez with Gelato.

Runtz has a reasonably rich terpene and cannabinoid profile. It is one of the tastiest and highly potent strains right now, with 27% THC and guaranteed large yields. It is priced at $9 per seed. Another advantage is that the seeds are feminized.

10 Most Potent Sativa Strains On The Market In 2021 — Photo by Christina Winter via Unsplash

Oracle

In 2009, a new mysterious strain gripped the cannabis sphere. Then, reports flying around claimed that the oracle strain could be the most significant breakthrough for cannabis potency. Everyone wanted to have a hit with this cultivar.

In the end, it turned out that it was all an over-hyped product. The oracle team put out a rumor that their strain has an enormous THC profile of up to 45%. The rumors also claimed the cultivar could complete its growth cycle in a shorter time than every other strain in existence. Because of these unproven anecdotal claims, the strain’s price skyrocketed to $1,000.

It wasn’t until 2013 that these claims were proven to be false. Not only did Oracle not grow in record time, but it also didn’t contain any reasonable amount of THC. It was a CBD-dominant strain as well.

Alternative: CBD Fix Automatic

It makes no sense to pay up to $1,000 for a CBD-based strain. Instead, you can purchase the CBD Fix Automatic strain, especially if you desire a similar experience as the oracle strain.

This Zamnesia-produced strain contains about 14% CBD and 0.8% THC. The hybrid emerged from a mix between Northern Light Auto and another CBD-rich descendant. It costs less than $10 per seed.

Isla OG

This cultivar has undefined origins. It first came to light when the famous rapper 2 Chainz smoked it on a 24-karat gold rolling paper. Right now, I believe that it was a perfect marketing stunt to peg its price at an excessive rate.

Expert cannabis geneticists said that they suspect sativa-dominant parents produced the cultivar. The two suspects were Hawaiian and OG Kush. The current price is unknown.

A Cheap Alternative: OG Kush

OG Kush offers a remarkably similar experience to Isla OG. All the more reason why OG Kush is often considered the strain’s potential parent.

OG Kush is popular among veteran and novice smokers alike. It is known for its high THC levels and unique flavors and aromas. With OG Kush, you get to get similar tastes and effects to Isla OG at a significantly lower rate. With $5, you can buy a seed of this feminized strain.

Bottom Line

Many breeders, including Zamnesia, offer highly potent strains for more reasonable prices. These strains were developed with the average smoker in mind. Not everyone can afford the most expensive strains on the market, so these affordable alternatives with great cannabinoid profiles aren’t out of place. Without breaking the bank, you can have a similar or better cannabis experience.

This article was created in partnership with Cannabis.net

5 TV Weed Moms We Love

Maria Loreto

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May 7, 2022

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Some of our favorite stoners are TV moms. What better time to honor them than on Mother’s Day weekend?

Despite the rise in marijuana use in moms, weed moms are not as common as you’d expect when it comes to pop culture. Their characters, usually funny and laid back, tend to exist in the background, with a few key exceptions.

Still, weed moms have become increasingly popular over the years, from characters that used to be controversial, to plain cool in today’s climate.

To celebrate Mother’s Day, here are 5 TV weed moms we love.

Nancy Botwin, “Weeds”

https://www.youtube.com/watch?v=aimnmPSVy7c

“Weeds” was released in 2005 and it was ahead of its time for a variety of reasons. Not only did it touch on cannabis during a time when it was illegal, it chose to do it through a suburban mom, who throughout eight seasons grows into a ruthless drug dealer. Nancy Botwin was a complex character, much like the male protagonists of the prestige shows of the era. Flawed female characters have become more common nowadays, but “Weeds” remains impressive in its commitment to exploring Nancy’s depths, no matter how far and disastrous.

Frankie, “Grace and Frankie”

https://www.youtube.com/watch?v=RTepsRTfh28

“Grace and Frankie” is currently in its seventh and final season. Initially pitched as a show about two mismatched women who end up having to live together after their husbands divorce them and marry each other, in later seasons Grace (Jane Fonda) and Frankie (Lily Tomlin) grow into best friends and companions. Frankie is also a stoner since the minute she appears onscreen, quietly luring Grace to the dark side. In short, they’re both stoners, and “Grace and Frankie” is a stoner show.

Kitty Forman, “That ’70s Show”

“That ’70s Show” was a family-geared sitcom set in the 1970s. The showrunners managed to imbue their series with a lot of weed, even if it wasn’t apparent to younger viewers. Kitty Forman, the mother of protagonist Eric Forman, is not only one of the funniest characters of the series, but she also has some memorable high scenes.

Bobbi Wexler, “Broad City”

“Broad City” is one of the most memorable stoner shows out there. Throughout its five-season run, Ilana and Abbi got high and did stupid things in New York City. Bobbi Wexler, Ilana’s mom, who had a small recurring role, made the most of her time on screen. In one scene, she memorably gets high with her sister, played by Fran Drescher, while bonding over their family history.

Ruth, “Disjointed”

https://www.youtube.com/watch?v=hQc2fv7VZ-k

“Disjointed” stars Kathy Bates as Ruth, a cannabis advocate who hires her son and a group of budtenders to tend to her newly opened cannabis dispensary. The series lasted one season, but it was a personal project for Bates, who explained she turned to cannabis when dealing with her breast cancer diagnosis.

The Fresh ToastThe most trusted name in cannabis

National Institutes of Health said that research about the health effects of cannabis use remains limited, even though one in four cancer patients have reported using cannabis products to manage their symptoms.

Cannabinoids In Cancer Treatment

Marijuana & Research

There are more studies ongoing to help shed light on how the body and endocannabinoid system in autistic people respond to cannabinoids.

What The Studies Say

Conclusion

A new study claims to erase and manage conditions like anxiety and alcohol abuse via gene editing.

Thailand residents will be permitted to legally cultivate “as many cannabis plants” as they wish in their own homes as of June 9.

While you may want to buy legal cannabis at the age of 18, that will be quite impossible since provisions and policies put in place by weed legalized states do not permit it.

Colorado

Washington

Alaska

Oregon

Washington, D.C.

California

Maine

Massachusetts

Nevada

Michigan

Vermont

Guam

Illinois

New Jersey

Montana

South Dakota

Arizona

New York

Virginia

New Mexico

Connecticut

Conclusion

Due to exorbitant taxes, California’s legal cannabis market has not come anywhere near to meeting its expectations in terms of size.

Cultivation Tax Has To Go

The Market Is Stunted

Weed Taxes Compared To Neighboring States

No Farmers, No Weed: What’s To Be Done?

Cannabis has never been easier to access. Here’s a quick guide for returning users.

Is weed stronger now?

What is CBD?

What method is best?

What about bad highs?

How do I navigate a dispensary?

South America’s cannabis marketplace shows signs of promise as incremental progress has been underway for several years. Recently Argentina Legalizes Medical Cannabis

Divided Opinions

Not everyone can afford the most expensive strains on the market. These affordable alternatives with great cannabinoid profiles are a solid option.

Fruity Pebbles

Cheap Alternative: Runtz

Oracle

Alternative: CBD Fix Automatic

Isla OG

A Cheap Alternative: OG Kush

Bottom Line

Some of our favorite stoners are TV moms. What better time to honor them than on Mother’s Day weekend?

Nancy Botwin, “Weeds”

Frankie, “Grace and Frankie”

Kitty Forman, “That ’70s Show”

Bobbi Wexler, “Broad City”

Ruth, “Disjointed”

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