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Dr. Mechoulam On Endocannabinoid System And Beyond

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The world of medicine will never be the same thanks to Dr. Raphael Mechoulam, the chemist responsible for the discovery of the endocannabinoid system, but the scientist who laid the groundwork for our modern understanding of cannabis says there’s still a lot of work to be done.

“I can’t list all the physiological systems and conditions affects by cannabinoids because there are too many,” exclaimed Mechoulam. He was the keynote speaker at the Marijuana for Medical Professionals conference in November.

Pamela Clum and Susan Squibb work at CBDRx, a business to business company looking to expand their manufacturing operations after their initial proof of concept. If you don’t know about CBDRx, their line of products are available online and are legal to ship anywhere in the U.S. They are well-known for their vegan CBD capsules, tinctures and infused honey and coconut oils. Ms. Squibb is the head of operations and Ms. Clum heads up R&D. You can see Clum’s video explainer of what CBD is here.

“Considering all of the promising basic research being conducted, this sort of medically focused conference is a call to action for more clinical trials”, according to Clum.

Cannabis’ Outsider Status

Normally, drug research and development takes place and is then introduced to the establishment, the people. But as Clum explained, the medicinal use of marijuana is a people driven movement.

Clum is a botanist who has been formulating in the medical marijuana industry since 2009. She works with the CBDRx hemp farm, which was the first certified organic hemp farm in US. CBDRx also run a genetic breeding program for the plant. Currently, there’s a lot of talk about CBD and THC. They predict that CBC and CBG will prove to be the up and coming therapeutic cannabinoids.

A Master Class With Dr. Mechoulam

To hear the keynote speech by Mechoulam was to gain a peek inside the great mind that was the first to think about cannabis at the molecular level. His unbiased perspective enabled him to see the science behind the prohibited plant, and his fascination with how it worked lead him to discoveries upon which all modern cannabis research is based.

Mechoulam presented his studies and the data at the medically accredited lecture. Imagine hearing him explain all of his work over the years. The organic chemistry lesson when over the heads of many of the attendees but one thing that was not lost was his request for more clinical trials.

“I hope someone will have the background to try and see if brain damage can be lowered by endogenous cannabinoids,” Mechoulm said to the audience from his homeland of Israel.

“Cancer has essentially no clinical trials with cannabinoids and although most patients use one type, there’s not one published cannabis trial on cannabis patients.” Cancers are so different from one another.

“There is nothing,” said Mechoulam in a firm tone, “not one single clinical trial.”

Mechoulam sees huge potential for research in that area, specifically whether cancer patients will benefit from THC, or another cannabinoid, or when or how to deliver the medicine, or the ratios.

“This is a shame and I hope within the next few years, cancer clinical trials will be undertaken and published.” While there is one underway in Israel for brain cancer, it’s a far cry from definitive.

Weekly Delight: Why You Should Follow AnimalsBeingNice on Instagram

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The world is often a cold, indifferent, and cruel place. There are wars, famines, despots taking power, too much black pepper on sandwiches, the recurring realization that one day you and everyone you love will die, and all kinds of other awful things. But it’s important to remember that there’s some good out there too, like the very kind animals featured on the excellent Instagram account AnimalsBeingNice.

We highly suggest following AnimalsBeingNice for some photos of good critters being good to each other in order to balance out the—let’s be honest—mostly mediocre travel and food pics your friends are constantly sharing. In addition to happy pictures of animals being nice, the account also offers perfect captions.

For example, here’s a photo of a duck imitating some flamingos, with the caption, “Friendly quack hanging out with the flamingos , having a nice time all around”

https://www.instagram.com/p/BM7kOGgAoXk/

And here’s another one of two bunnies kissin’, accompanied by the caption, “Long eared friends being nice.”

https://www.instagram.com/p/BNHr2_egDai/

“Furry friend kisses the water boy , you look nice, this is nice,” the account writes about a photo of a puppy smooching a large goldfish.

https://www.instagram.com/p/BMyoqoigErp/

Here’s a pug “being nice to the dragon.”

https://www.instagram.com/p/BMewL-tg3ug/?taken-by=animalsbeingnice

We really love this photo of a hen sitting on a puppy’s head, about which Animals Being Nice writes, “That’s really nice of you.”

https://www.instagram.com/p/BMaDJxdgJcw/?taken-by=animalsbeingnice

“Thanks for being nice” the account writes about this loyal kitten sitting inside the cone of his dog buddy.

https://www.instagram.com/p/BMShjgRArJu/?taken-by=animalsbeingnice

What else is there really to say about this photo of a bulldog and cat holding each other other than, “Nice friends.”

https://www.instagram.com/p/BMIHCLzgRdi/?taken-by=animalsbeingnice

No caption will ever top the one accompanying this photo of a porpoise blowing an air kiss at a young child at an aquarium: “Hello friend , boop”

https://www.instagram.com/p/BMIG0aKgwuw/?taken-by=animalsbeingnice

While this account has only been around for about a month, we look forward to browsing through it for years to come–if the world doesn’t end first 🙂

Watch Construction Workers Uncover A Very Angry Bear During A Dig

Imagine you’re a construction worker, just doing your job and digging some holes on a chicken farm when suddenly you uncover a big ass bear who’d been buried under the ground. Just such a thing recently happened to some workers in Bolu, Turkey.

The Daily Mail reports the workers discovered the bear by accident, giving them “the shock of their lives”

But a note on a YouTube clip of the video says the workers actually rescued the bear. Fom the YouTube: “…[T]he men came to the assistance of a grizzly bear fell in a septic tank. The bear had ventured out to a farm to eat the chickens and fell in the tank concrete septic tank. The rescue operation has need to dig the ground to access the tank buried in the ground. A hydraulic hammer attached to an excavator has then created a hole in the tank large enough so that the animal can get out.”

So the workers were either heroes who saved the life of a chicken-chasing grizzly or they’re accidentally rude guys who disrupted a huge and scary bear as it was trying to hibernate. It’s also possible there’s a third explanation, since the Daily Mail and YouTube comments aren’t always the most trustworthy source of news. Regardless, the video is a good one, and it has a happy ending: The bear eventually escapes the hole and runs away, apparently uninjured.

Watch it below:

Here Are The “Best” Black Friday Fight Videos of 2016

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As we’ve noted, Black Friday is a holiday tradition for which millions of Americans deprive themselves of sleep to buy discounted goods for their families or themselves. Of those millions, a few dozen or hundred lose perspective/their minds and turn violent when they can’t get the on-sale item they desire. Here are some videos of those unfortunate few brawling in big box stores around the country.

Here’s a CNN report that discusses and shows video from several fights over big screen TVs.

Also via CNN, here’s aclip of a brawl at a mall at the Vintage Faire Mall in Modesto, California.

A fight broke out in a parking lot at the Houston Premium Outlet in Houston, Texas early Friday morning over a parking lot, according to KRPC. “I just couldn’t believe they were fighting like this on a day where we’re supposed to give thanks,” the person who shot the video told the local news station.

And here’s a compilation of several Black Friday fights, all of which purportedly took place this year.

Messy breakups, deranged antics, pets gone wild. The Internet car-crash you can’t turn away from. For more, check out “New Zealand Man Takes His Homemade Jet Boat Out On Flooded Streets,” “Watch: Deer Trapped in American Eagle Store Smashes Through Front Window,” and “Cops: Florida Man Stabbed IHOP Waiter In Retaliation For Food Poisoning.

 

11 Annoying Things About Menus

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Dining. Sure, it’s one of our favorite past times, but it has also become a lesson in rage control. From the moment you’re seated and open the menus, the clock starts ticking on the time-bomb of indignation in your head. What the hell does mélange mean?

With many descriptions, it’s not so much the restaurant’s fault, it’s society’s. Adjectives like “grass-fed,” “housemade” and “farm-to-table” used to have value; the words differentiated the independently owned restaurants that went out of their way to procure high-quality ingredients from small farms. But now, because of gross overuse, those same words that once propelled businesses up the restaurant food chain are now simply buzzwords that have lost their meaning.

But then, there are some really dumb terms that serve little purpose.

Here are 11 of the most irritating offenses found on restaurant menus.

1) Hen egg
Well, duh. If it’s a duck egg or dodo egg or whatever else, that’s the time to list the species. Otherwise, it’s assumed the egg you’re about to order comes from a hen.

https://www.instagram.com/p/BEPL5SRjhDE/

2) Describing anything as “cooked to perfection” or “perfectly cooked.”
How much for the poorly cooked steak?

https://www.instagram.com/p/5TW2yzm8Gy/

3) Inaccurate menu descriptions
When you hate mushrooms and your noodles come piled high with shiitakes. Or your risotto is more farro than rice (farrotto) and nobody told you. Menu, you had one job!

https://www.instagram.com/p/BKluT8Zh2S2

4) Foam
Is there a less appetizing term? Why don’t you just call it spit? Or “tempered air” like this person.

https://www.instagram.com/p/BJNcxLPh-gQ/

5) Describing inherently gluten-free items as “gluten free.” 
That ice cream is gluten-free? And the wine, too? You don’t say!

https://www.instagram.com/p/11vPPBiG5a/

6) Hand-crafted, hand-cut, hand-breaded
How are the other items on your menu made?

https://www.instagram.com/p/BKl7ioHAw4H/

7) Fresh
So, what you’re saying is, we’re not eating garbage?

https://www.instagram.com/p/BKoKiC_gIbU/

8) Ice program
Doing cool things with ice is nice, but it couldn’t sound more pretentious. Kind of like having a water sommelier.

https://www.instagram.com/p/BJ3cC78gFph/

9) Deconstructed
The term is outdated. What used to be code for “ambitious” is now a tired term for “trying too hard.”

https://www.instagram.com/p/BID64B1jMOM/

10) Quotation marks
Nothing is more unsettling than seeing a menu item hugged in quotes. As one chef acknowledged, “It’s basically a disclaimer that you’re going to be ‘disappointed’ when your ‘PB&J’ arrives and it’s just a caramelized fig with cashew dust.”

https://www.instagram.com/p/BKndkuxDWij/

11) Chef-driven
Is there any other kind of menu? Unless you’re a fast-food joint, it’s an unnecessary statement.

https://www.instagram.com/p/8g3r6MIRYc/

Did we miss your menu gripe? Let us know in the comments!


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What I Eat: Behind The Scenes With ‘It’s A Wonderful Life’ Star

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“I love to eat,” says Karolyn “Zuzu” Grimes, the actress who played the iconic cherubic young daughter of George Bailey (played by Jimmy Stewart) in the timeless holiday classic, It’s a Wonderful Life. “I like Christmas cookies and I always fix a prime rib roast for Christmas dinner. That’s tradition.”

For Grimes, the holiday season is tumultuous, emotional and full of traveling, yet she still has time to make a big family meal for Christmas, which also includes a green bean casserole.

“I use Campbell’s cream of mushroom soup, cheese and French’s dried onions,” she says. “For the cheese, I use cheddar. Tillamook. That’s all I cook with — I love Tillamook!”

For Grimes, the joyous grind of traveling during the holiday season started in 1980 when It’s a Wonderful Life, which had previously been thought of as a flop, earned a resurgence. People started to approach Grimes for interviews and she started receiving fan mail. Then, in 1993, she was hired by Target, which reunited the Bailey children for a holiday campaign.

Now Grimes, 76, is on the road every holiday season, traveling from her home in Port Orchard, WA, to Dallas, Portland, L.A., Indianapolis and many more locations around the country for appearances.

“I like being on the road and meeting the people and enjoying the love that comes from the folks for the film,” she says. “I didn’t realize that anything like that could happen.”

Grimes recalls shooting the film, which debuted December 20, 1946. She says some cast members took on roles to play extras just for the food spread.

“During the swimming pool scene,” she recalls, “they put on the most elaborate catering and some of those kids decided to do the part just so they would eat. Where I worked it was mostly on set and we’d eat in the studio cafeteria.”

But what would she find herself munching on between takes?

“Probably a hot dog,” she laughs. “Though I didn’t like food much when I was little; I thought eating was a waste of time, same with sleeping. Needless to say I’ve gotten over both of those things!”

Grimes’ father, a former manager at a Safeway store, would bring home food for dinners like “lamb chops and pork chops and rabbit and chicken,” she says. “And I couldn’t tell the difference! So I grew up eating a little bit of everything.”

Now, though, she often has her eyes on the next meal. But, she says, despite all her traveling, she is not a happy consumer of airplane food.

“I try not to eat on an airplane,” she says, somberly. “Their food is not the best. But I do love all kids of food! I’ve gotten to know restaurants in the airports and I like to eat the food in whatever region I travel to. Whether it’s Creole or Cajun, I love to try anything new!”

When she goes back to the east coast, Grimes looks for a good steak.

“I like the corn-fed steak, which isn’t good for you,” she laughs. “But that’s okay, that’s okay.”

And when she’s in Chicago, she goes for hot dogs.

“With relish and mustard!”

But the restaurant that gives her the most pause is a place called Parker’s Grille in Seneca Falls, New York — the town that inspired the fictional locale of Bedford Falls in the movie and where a museum for the film exists today.

“Thinking about them, that hits me hard,” she says. “They have really good food.”

Love-Struck Man Gets Stuck Between Two Buildings for Hours

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Listen, my women. If a guy leads you to a roof at 2 a.m., it might seem romantic at first. If he hands you his beer and says “watch this,” get your Uber queued up because it’s time to go home.

Grant Birdsong, a 22 year old University of Pittsburgh student, did exactly that (minus or plus the beer, it’s unclear) in the city’s Oakland neighborhood early this morning. He was trying to impress a girl — a whole new world, shining, shimmering, splendid — by leaping between buildings. He missed, fell three stories, and was wedged between a Qdoba and Bruegger’s Bagels.

The Forbes Ave. roofs in question.
The Forbes Ave. rooftops in question.

Paramedics rappelled down to reach him, and eventually had to jackhammer a hole in the wall of the Qdoba to pull him out. There are worse ways to exit a Qdoba, but this is pretty high up there.

After four hours of work, he was free, with only a broken ankle and two thumbs up to his girl. She waited outside the whole time, the local CBS station reports. Tell us princess, when did you last let your heart decide?

 

Watch The World’s Most Optimistic Sports Fan Pie Himself With Nachos

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Come with us on a journey with an Everyman on the edge of greatness. He’s in line at PNC Park in Pittsburgh. He’s wearing a perfectly crisp white t-shirt. He pays too much money for a massive plate of stadium nachos. And then.

Today’s the day I catch a ball, he says to himself. He was almost correct. This would be the day he became Internet Famous for catching something else.

Pirates’ infielder Jung Ho Kang chips a foul ball, and Nacho Man sees his chance. His left hand shoots straight up, grasping ineffectually at the air as the ball soars way, way over his head. Meanwhile, his right hand puts the nachos straight into his own face.

In slow motion, the reactions of his fellow fans play out in Shakespearean tragedy: Forearms rise to block the debris, chins retreat into necks, little girls peer from behind rotund fathers to gawk at the poor schmuck. Our boy’s Miller Lite flies from its spot in the crook of his elbow like it’s diving to get out of the way, too. The hot cheese mixture cascades down his shirt.

https://vine.co/v/5bdJuL2I9O7

He did it to himself, indeed.

“I had a beer and some nachos and was ready to take my seat. The next thing I know the ball was right above my head and I did whatever I could to try and bring it in,” he said a Fan Morning Show interview, Pittsburgh’s CBS local reports. For his valiant efforts, the Pirates awarded Nacho Man a clean shirt and an emoji thumbs-up on Twitter.

We’ve obtained footage of the man moments before the nachos hit the fan:

Boston Resident Claims CNN Accidentally Aired Hardcore Porn For 30 Minutes Thanksgiving Night

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Some Boston-area CNN viewers who managed not to eat and drink themselves to sleep by 10 p.m. were reportedly treated to a special surprise Thanksgiving night: 30 minutes of hardcore pornography. NSFW screenshots from the purported porn airing are below.

Twitter user @solikearose claims she tried to watch a marathon of Antony Bourdain’s Parts Unknown that aired at 10 pm (she appears to be watching it via DVR based on the screenshots in her tweets) and instead found herself looking at the now well-known private parts of porn stars.

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The Next Web reports that RCN, a local television provider based in New Jersey, is likely responsible for the mix-up. Apparently, CNN sent the correct video feed but someone at RCN hit the wrong button, sending pornography into an unknown number of households in the Boston area. Since @solikearose appears to have recorded the show and watched it about an hour later, it also seems possible her TiVo somehow recorded one of the porn channels instead.

RCB hasn’t offered an explanation or apology as of this writing, but someone from their Twitter account did tell @solikearose that they hadn’t received any complaints from other customers.

screenshot-2016-11-25-11-59-55

Later, @solikearose said a representative from RCN told her that everything was “working perfectly” last night when Bourdain’s explorations were reportedly interrupted by hardcore porn.

screenshot-2016-11-25-12-00-06

@SoLikeARose has since made her account private, so perhaps it was all a very good hoax or maybe RCN goons got to her. If you were one of the other households affected, let us know at: taylor@thefreshtoast.com.

Messy breakups, deranged antics, pets gone wild. The Internet car-crash you can’t turn away from. For more, check out: “’Tough Babe’ Grandmother Punches Bear in Face During Attack,Watch A Vodka-Chugging, Nearly-Naked Norwegian Madman Frolic In An Ice-Covered Forest,Woman Slaps Bouncer After He Refuses to Accept Pizza Slice As IDand “Cops: Florida Man Stabbed IHOP Waiter In Retaliation For Food Poisoning.

Grandmother’s Accidental Text Turns Into Tasty Thanksgiving Meal For Confused Teen After Viral Tweet

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“This has come out of nowhere for us, and it’s funny to my family,” her grandson Brandon Burgoyne told the Republic.

Ten days ago, Wanda Dench texted her grandson to remind him about the Thanksgiving dinner she was hosting. The only problem was Dench’s grandson changed his phone number last May, so the text went to 17-year-old Jamal Hinston instead. Hinston was understandably confused and tickled by the initial text exchange, a screenshot of which his posted to Twitter.

The tweet went viral and has since been retweeted over 210,000 times.

“I thought it was very odd that my grandson would ask for a picture of me,” Dench said later. “I was so embarrassed…so I said, ‘Sure, come on over. Grandmothers feed all.’ And he took me up on my offer.’”

Yesterday afternoon, the Arizona Republic reports Hinston made good on his promise and stopped by Dench’s Thanksgiving dinner, though he forgot the pumpkin pie he’d said he’d bring.

“We’ve got plenty,” Densch told him when he arrived. “Let’s got in and take a look at the turkeys.”

“Everybody seems so nice and sweet,” Hinston told a reporter who stopped by the dinner. “I’m happy to be here. I never met her before…and she welcomed me into her house, so that shows me how great of a person she is.

The only downside to the feel-good story? Hinston forgot to blur out Densch’s phone number in his initial tweet, so she received over 600 texts, many of which were from people asking if they too could join her for Thanksgiving dinner. Not that there were any hard feelings.

“This has come out of nowhere for us, and it’s funny to my family,” her grandson Brandon Burgoyne told the Republic.

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